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  • Title: Ultrastructural studies on bone marrow development in embryonic mice.
    Author: Bessler H, Djaldetti M.
    Journal: Biol Neonate; 1992; 61(4):243-52. PubMed ID: 1610954.
    Abstract:
    The hematopoietic events in the embryonic C57B1/6J mouse bone marrow have been followed by electron microscopy. The first type of cells to appear in the embryonic bone marrow were mesenchymal cells identified at day 15 of gestation. The first recognisable hemopoietic cells to appear were those of the granulocytic series identified as mature cells at day 18, although single red cell precursors were also found at this gestational stage. The real erythroid development was noted on the last days of gestation (days 20 and 21), when also cells of the megakaryocytic series were found. At birth, day one of newborn life, all hematopoietic elements were present. The pattern of hematopoietic development in the embryonic bone marrow was compared to that observed in other embryonic hematopoietic sites.
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