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  • Title: [Role of initial hemodynamic status and rate of blood loss replacement in postresuscitation changes in blood circulation and animal mortality].
    Author: Zarzhetskiĭ IuV, Trubina IE, Zaks IO, Volkov AV.
    Journal: Biull Eksp Biol Med; 1992 Feb; 113(2):120-2. PubMed ID: 1611047.
    Abstract:
    In 43 experiments performed on narcotized dogs after 10 min clinical death induced by exsanguination, the peculiarities of postresuscitation changes in the blood circulation associated with the initial hemodynamic status, the rate of the blood loss replacements after restoration of cardiac activity, and the use of infusion therapy by albosorb (specifically processed albumin) were studied. The effect of the initial level of stroke index (SI) on the pronouncement of postresuscitation derangements in the central hemodynamics (CHD) and on the resuscitation outcome was determined. With the initial value of SI being mean, the maintenance of a moderate blood deficit (10 to 15 ml/kg) within the first hour of restoration was accompanied by an improvement in the survival rate of the animals as compared with a rapid and complete replacement of the blood. The infusion of albumin and creation of a moderate overtransfusion by the first hour post resuscitation removed the prognostic value of the initial SI.
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