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  • Title: Prostate cancer: the role of hormonal therapy.
    Author: Salesi N, Carlini P, Ruggeri EM, Ferretti G, Bria E, Cognetti F.
    Journal: J Exp Clin Cancer Res; 2005 Jun; 24(2):175-80. PubMed ID: 16110748.
    Abstract:
    Prostate cancer is the cause of more than 1% of all deaths in men. Its incidence is increasing by 2-3% per year. The general prognosis for diagnosed prostate cancer remains poor, with 70% survival at 10 years compared to the general population. About 50% of the cases are diagnosed at a locally advanced stage, and about 30% have bone metastases at the time of diagnosis. Adjuvant systemic treatments (hormones or chemotherapy), which are effective for advanced-stage disease, might have a greater role in early-stage disease. Advanced prostate cancer is an incurable disease. Treatment objective is palliation only. Here, we review the major controversies concerning hormonal therapy, and provide a general approach to management of patients with early-stage and advanced prostate cancer.
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