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  • Title: Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1.
    Author: Semenza GL.
    Journal: Proc Am Thorac Soc; 2005; 2(1):68-70. PubMed ID: 16113471.
    Abstract:
    Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls transcriptional responses to hypoxia. HIF-1 plays critical roles both during development and in response to physiologic and pathophysiologic stimuli in the adult. Here, the involvement of HIF-1 in lung pathophysiology will be discussed.
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