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  • Title: Asystole and severe bradycardia in preterm infants.
    Author: Dorostkar PC, Arko MK, Baird TM, Rodriguez S, Martin RJ.
    Journal: Biol Neonate; 2005; 88(4):299-305. PubMed ID: 16113524.
    Abstract:
    UNLABELLED: Transient episodes of apnea and bradycardia are common in preterm infants. Pronounced asystole or sinus arrest, however, is relatively rare and the clinical significance of such events is unknown. OBJECTIVE: The purpose of our study was to: (1) evaluate the prevalence of severe bradycardic and asystolic events in infants studied with polygraphic cardiorespiratory monitoring, (2) characterize these events, and (3) correlate the events with other clinical findings. METHODS: A total of 583 studies were performed in 454 preterm infants at a post-conceptional age 37.4 +/- 2.5 (range 34-42 weeks). Asystolic pauses were defined as no QRS complex for >or=3 s consistent with a heart rate <20 beats per minute (bpm). Severe bradycardia was defined as no QRS for >or=2 s consistent with a heart rate of 21-30 bpm. RESULTS: Eight infants (29.5 +/- 3.9 weeks' gestational age, birth weight 1,283 +/- 445 g) met the criteria of having had at least 1 asystolic event (heart rate <or=20 bpm). These infants had a total of 32 episodes of bradycardia <or=30 bpm, of which 22 episodes were classified as asystole. During the asystolic episodes, the P-R interval remained unchanged in 21 of 22 episodes and prolonged in 1. One patient had non-sustained ventricular tachycardia before resumption of normal sinus rhythm. All asystolic events were associated with apnea (mean duration of 17.7 +/- 9.4 s) and O(2) saturations fell by 10 +/- 6%. A pH probe study was available in 9 of 22 asystolic events and 6 of 10 severe bradycardic events. Gastroesophageal reflux was temporally related to only one asystolic and two bradycardic events. Clinical follow-up of these infants at a mean age of 14 months (range 1-46) reveals no symptomatic sequelae; although 1 infant died from multisystem failure associated with multiple congenital anomalies. CONCLUSIONS: Asystolic pauses occur in 1.8% of a selected population of preterm infants who have been experiencing cardiorespiratory events, are related to respiratory pauses, and appear to have a benign long-term outcome, although future study should incorporate long-term neurodevelopmental outcome.
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