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  • Title: [Effect of focal hypothermia on traumatic brain edema and the content of lactic acid in the brain tissue in rats].
    Author: Liang YM, Liu YS, Qu HT, Wang GW, Li CH.
    Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2004 Dec; 29(6):678-81. PubMed ID: 16114556.
    Abstract:
    UNLABELLED: Objective To investigate the effect of focal hypothermia (LH) on traumatic brain edema and the content of lactic acid in rat brain tissue. METHODS: One hundred and sixty-eight adult SD rats were randomly divided into 6 groups: Group A, sham injury group; Group B, traumatic brain injury controlled group; Group C, treated by LH with water at 0 degree C; Group D, treated by LH with water at 10 degrees C; Group E, treated by LH with water at 20 degrees C; Group F, treated by LH with water at 25 degrees C. All rats except those in Group A were subjected to traumatic brain injury (TBI) with Feeney's method. LH began for animals in Group C - F 30 minutes after the TBI. Regional brain temperature reached the target temperature of 31 degrees C within 20-30 minutes and maintained for 3 hours. Each group was divided into 4 sub-groups by investigating the duration after the TBI: 1, 3, 5 or 7 day sub-group. At the end of investigation, the rats were killed and water content (WC) and concentration of lactic acid (LA) in the brain tissues were measured. RESULTS: Compared with Group A, WC and LA of Group B increased significantly at each investigation duration (P < 0.05). Compared with Group B, WC and LA of Group C did not change (P > 0.05), but those of Group D, E, and F decreased significantly (P < 0.05). WC and LA of group C were the highest among Group C - F. CONCLUSION: Focal hypothermia with water of 10 degrees C, 20 degrees C, and 25 degrees C but not 0 degrees C has some effect on traumatic brain edema and the temperature at 20 degrees C and 25 degrees C are the better. The mechanism of focal hypothermia may be associated with inhibiting acidosis of lactic acid.
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