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  • Title: Survival in two variants of tau-negative frontotemporal lobar degeneration: FTLD-U vs FTLD-MND.
    Author: Josephs KA, Knopman DS, Whitwell JL, Boeve BF, Parisi JE, Petersen RC, Dickson DW.
    Journal: Neurology; 2005 Aug 23; 65(4):645-7. PubMed ID: 16116138.
    Abstract:
    Pathologic diagnoses in frontotemporal lobar degeneration (FTLD) include tau-positive FTLD and tau-negative FTLD. Two variants of tau-negative FTLD are FTLD with motor neuron disease (FTLD-MND) and FTLD with motor neuron disease type inclusions but without motor neuron disease (FTLD-U). An analysis of patient outcomes in these cases reveals that FTLD-MND has significantly shorter survival than FTLD-U, suggesting that FTLD-MND is a more aggressive disease process.
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