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  • Title: [Clinical studies on the influence of Ornipressin (POR 8) on the cardiovascular system in general anesthesia].
    Author: Hemprich A, Niemeyer K, Wöffen H, Hemprich A.
    Journal: Dtsch Zahnarztl Z; 1992 Jan; 47(1):48-50. PubMed ID: 1611979.
    Abstract:
    A clinical prospective study of 231 patients was conducted to examine the influence of Ornipressin (POR 8) on the cardiovascular system. The standard concentration of the vasoconstrictor was 0.2 i.u./ml. A control group of 34 patients received 0.9% NaCl solution. In less than 10% of all cases blood pressure or pulse frequency changed up to 30 mmHg or 30 bp. m. Cardiac arrhythmias without clinical relevance could be observed sporadically. There were significant differences to the control group only in terms of pulse rate under volatile anaesthetics, and changes in blood pressure during the first 10 minutes under neurolept analgesia and under combined anaesthesia.
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