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  • Title: Turn residues in beta-hairpin peptides as points for covalent modification.
    Author: Cooper WJ, Waters ML.
    Journal: Org Lett; 2005 Sep 01; 7(18):3825-8. PubMed ID: 16119908.
    Abstract:
    Beta-turns are important sites for protein-protein and protein-peptide interactions, but little research has explored synthetic modifications of turn residue side-chains in a beta-hairpin peptide. To this end, beta-hairpin peptides were synthesized containing the type I' turn sequence Val-Asn-Gly-Lys with modifications at Asn and Lys. We found that these variations impose a small penalty, demonstrating that beta-turns are capable of displaying a range of functionality, which may be exploited for biomolecular recognition and medicinal applications. [structure: see text]
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