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  • Title: DNA damage initiates photobiologic reactions in the skin.
    Author: Horio T, Miyauchi-Hashimoto H, Okamoto H.
    Journal: Photochem Photobiol Sci; 2005 Sep; 4(9):709-14. PubMed ID: 16121281.
    Abstract:
    Ultraviolet (UV) radiation can induce acute and chronic photobiologic reactions in the absence of exogenous chromophores. Nuclear DNA is a major chromophore to initiate UV-induced physiologic reactions. The XPA-gene deficient mouse, an animal model of xeroderma pigmentosum, develops increased photobiologic reactions including acute inflammation, immunosuppression and skin cancers, because of the defect in the excision repair of UV-induced DNA lesions.
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