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  • Title: Spontaneous regression of retinoblastoma in a Taiwan series.
    Author: Kao LY, Yang ML.
    Journal: J Pediatr Ophthalmol Strabismus; 2005; 42(4):228-32. PubMed ID: 16121553.
    Abstract:
    PURPOSE: To document the high occurrence of complete spontaneous regression of retinoblastoma in a Taiwan series. PATIENTS AND METHODS: Cases of retinoblastoma (133 eyes of 110 patients) at a single Taiwanese hospital from 1978 to 2002 were reviewed. RESULTS: Complete spontaneous tumor regression and phthisis bulbi were noted in 7 eyes of 7 patients. The regression rate was 5.3%, which is higher than previous reports of 1% to 2%. Tumor regression was associated with a common course of acute painful inflammation and ended with a shrunken, nonfunctioning eye. No residual vision was noted in any patient. CONCLUSION: Delayed diagnosis and advanced stage of the disease in this series of Taiwanese patients probably led to the massive intratumoral necrosis and resulted in phthisic change of the globe.
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