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  • Title: Equality of the sexes: found in translation.
    Author: Ray PS, Fox PL.
    Journal: Cell; 2005 Aug 26; 122(4):492-3. PubMed ID: 16122416.
    Abstract:
    Male fruit flies (and humans) have half the number of X chromosomes that females have, yet the expression of X-linked proteins in males is the same because of a sex-specific compensatory mechanism. In this issue of Cell, report that a unique two-stage translation silencing mechanism thwarts synthesis of a male-specific transcription activator in female flies, ensuring that gene dosage compensation occurs only in males.
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