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  • Title: Comparison of L-hyoscyamine, glucagon, and placebo for air-contrast upper gastrointestinal series.
    Author: Moeller G, Hughes JJ, Mangano FA, Gelormini R, Tomlinson TL, DiPalma JA.
    Journal: Gastrointest Radiol; 1992; 17(3):195-8. PubMed ID: 1612300.
    Abstract:
    Previous studies have compared the use of anticholinergic drugs and glucagon for upper gastrointestinal (UGI) radiography. Many radiologists prefer glucagon because these comparisons showed it to have a shorter duration of action with fewer side effects. L-Hyoscyamine is the levo-rotatory form of atropine with minor adverse side effects. This study compared the effects of glucagon (N = 48), L-hyoscyamine (N = 43), and placebo (N = 45) on gastric and duodenal distension, mucosal coating, and patient tolerance. L-Hyoscyamine provided gastric and duodenal images equal in quality to glucagon. Except for the more frequent reporting of dry mouth with L-hyoscyamine, side effects were not different among the groups. L-Hyoscyamine is an economical alternative to glucagon for hypotonic gastrointestinal radiography.
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