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  • Title: Involvement of PGE2 and TNF-alpha in LPS-tolerance in rat glial primary cultures.
    Author: Shemi D, Kaplanski J.
    Journal: Prostaglandins Leukot Essent Fatty Acids; 2005 Nov; 73(5):385-9. PubMed ID: 16125920.
    Abstract:
    The effect of repeated exposure of primary newborn rat brain glial cultures to the endotoxin lipopolysaccharide (LPS), a component of Escherichia coli membrane, on PGE(2) and TNF-alpha production was examined. PGE(2) production by cell cultures exposed to LPS at a dose of 5 microg/ml, 4 and 24 h after initial exposure did not differ from PGE(2) production by the same cultures 4 and 24 h after the first exposure to the same dose of LPS. TNF-alpha production was significantly lower with the second exposure as compared with the production by the same culture, exposed to the same dose of LPS, examined 4 and 24 h after the first exposure. We concluded that endotoxin tolerance in our culture model is associated with reduced secretion of TNF-alpha, caused by the initial exposure to LPS, while PGE(2) production remained unchanged.
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