These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The value of c-kit mutational analysis in a cytokeratin positive gastrointestinal stromal tumour.
    Author: Rossi G, Sartori G, Valli R, Bertolini F, Bigiani N, Schirosi L, Cavazza A, Luppi G.
    Journal: J Clin Pathol; 2005 Sep; 58(9):991-3. PubMed ID: 16126886.
    Abstract:
    The expression of cytokeratins in gastrointestinal stromal tumours (GISTs) is rare and may lead to diagnostic confusion when it occurs. This report describes a metastatic GIST that stained strongly for cytokeratins, CD117, and CD34 in a patient who was previously diagnosed with gastric epithelioid angiosarcoma. A review of both tumours showed the same histological and immunohistochemical profiles, and c-kit molecular analysis revealed an insertional mutation at codon 558 of exon 11 in both tumours. Thus, pathologists should be aware that GISTs can occasionally express cytokeratins, and that c-kit mutational investigations may have a key diagnostic role and may prevent diagnostic mistakes that could have important clinical implications.
    [Abstract] [Full Text] [Related] [New Search]