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  • Title: Spontaneous major bleeding in acquired factor X deficiency secondary to AL-amyloidosis.
    Author: Enjeti AK, Walsh M, Seldon M.
    Journal: Haemophilia; 2005 Sep; 11(5):535-8. PubMed ID: 16128899.
    Abstract:
    Abnormal bleeding may be seen in up to a third of patients with amyloidosis. Factor X deficiency is the commonest acquired coagulopathy in amyloidosis. While mild intracutaneous bleeding is common, spontaneous life-threatening haemorrhage is rare. We report a case of acquired FX deficiency due to amyloid light chain (AL)-amyloidosis presenting with spontaneous retroperitoneal bleeding. The diagnostic and management issues in this patient are discussed.
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