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  • Title: Ultra-high redox enzyme signal transduction using highly ordered carbon nanotube array electrodes.
    Author: Withey GD, Lazareck AD, Tzolov MB, Yin A, Aich P, Yeh JI, Xu JM.
    Journal: Biosens Bioelectron; 2006 Feb 15; 21(8):1560-5. PubMed ID: 16129596.
    Abstract:
    We report on a highly ordered array of carbon nanotubes (CNTs) that serves as a universally direct nanoelectrode interface for redox proteins and provides an efficient conduit for electron transfer. The site-selective, covalent docking of the enzyme glucose oxidase (GO(x)) on the CNT tips is found to have a marked effect on enhancing electron transfer properties, as measured by cyclic voltammetry. A unimolecular electron transfer rate of 1500 s(-1) has been measured for this system, a value exceeding the rate of oxygen reduction by glucose oxidase. Furthermore, the redox enzyme-CNT array conjugate can be utilized as a quantitative, substrate-specific biosensor.
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