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  • Title: Amiodarone-related acute respiratory distress syndrome following sudden withdrawal of steroids.
    Author: Charles PE, Doise JM, Quenot JP, Muller G, Aube H, Baudouin N, Piard F, Besancenot JF, Blettery B.
    Journal: Respiration; 2006; 73(2):248-9. PubMed ID: 16131795.
    Abstract:
    Acute lung toxicity is a rare but classical complication of amiodarone therapy. We report the case of a patient who developed an optic neuropathy after 15 years of amiodarone administration, and who was treated for 2 weeks with steroids. Following withdrawal of steroids, the patient rapidly developed an acute respiratory distress syndrome. Postmortem lung histologic examination was consistent with amiodarone-induced pneumonitis. Since this complication is thought to be of immunological origin, we speculate that the sudden withdrawal of steroids was implicated in the development of the acute lung injury.
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