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  • Title: Over-representation of bcr3 subtype of PML/RARalpha fusion gene in APL in Indian patients.
    Author: Sazawal S, Hasan SK, Dutta P, Kumar B, Kumar R, Kumar L, Choudhry VP, Saxena R.
    Journal: Ann Hematol; 2005 Nov; 84(12):781-4. PubMed ID: 16132910.
    Abstract:
    Thirty six patients with acute promyelocytic leukemia were studied by reverse transcriptase-polymerase chain reaction (RT-PCR) and real-time PCR. There was concordance between the results achieved by both the methods except in one case, which was negative by RT-PCR but positive by real-time PCR. The prevalence of bcr3 (short isoform) was found to be significantly higher than that of bcr1 (long isoform) (64 vs. 36%, P=0.03). No correlation was found between age, sex, and white blood cell (WBC) count at diagnosis. Molecular remission was achieved in 66.6% of patients with bcr3 isoform. Median WBC count at presentation was found to be higher than that in the West.
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