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  • Title: [Effects of the glucosidorum tripterygll totorum on the proliferation and apoptosis of cell line HL-60 in human acute promyelocytic leukemia].
    Author: Liu J, Hu WX, Ye M, He LF, Zhang B.
    Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2004 Aug; 29(4):382-5. PubMed ID: 16134584.
    Abstract:
    OBJECTIVE: To determine the effects of the glucosidorum tripterygll totorum on the proliferation inhibition and apoptosis induction of cell line HL-60 in human acute promyelocytic leukemia. METHODS: The survival rates of cells were tested by MTT assay, fluorescence stain, flow cytometry test, and DNA fragmentation. RESULTS: Glucosidorum tripterygll totorum could notably reduce the survival rate of HL-60 cells, and inhibit the proliferation of tumor cells. The 50% inhibitory concentration (IC50) was 5.0 microg/ml and it arrested the cell cycle at G2/M phase (P < 0. 05). The typical apoptosis morphologic cells were seen, the rates of apoptosis cells were increased (P < 0.05), and DNA ladder appeared in the experiment group. CONCLUSION: Glucosidorum tripterygll totorum could notably inhibit the proliferation and induce the apoptosis of HL-60 cells.
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