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  • Title: [Effects of aspiration of airway dead space on blood gases and respiratory mechanics in acute hypercapnia model dogs].
    Author: Zhao W, Liu Y, Gao D.
    Journal: Zhonghua Jie He He Hu Xi Za Zhi; 2001 Nov; 24(11):643-6. PubMed ID: 16136899.
    Abstract:
    OBJECTIVE: To establish the method of aspiration of airway dead space (ASPIDS) and evaluate the effects of ASPIDS on elimination of CO2 and improvement of ventilation efficiency. METHODS: Using self-designed ASPIDS device, physiological parameters such as PaCO2, P(peak), P(pause), end expiratory carbon dioxide pressure (PaCO2), lung statistic compliance (Cst), respiratory resistance (Re) and hemodynamics in two animal groups of conventional mechanical ventilation (CMV) and hypercapnia (HC) were observed by applying tracheal gas insufflation (TGI 4.0 L/min) and ASPIDS (4.0 L/min). RESULTS: ASPIDS significantly decreased PaCO2 level, enhanced CO2 elimination and maintained PaCO in normal range while decreased VT by 30%, the elimination of CO2 of ASPIDS was superior to that of TGI. ASPIDS significantly decreased airway pressure in both animal groups . P(et)CO2 and Re levels significantly decreased after ASPIDS. ASPIDS showed no influence on Cst, hemodynamics and oxygenation. CONCLUSIONS: The ASPIDS device is a simple and practical adjunct method to mechanical ventilation, it can more effectively decrease PaCO2 than TGI, and maintain lower airway pressure.
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