These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Effects of an antioxidant (An7845) on the proliferation and apoptosis of K562 leukemia cells].
    Author: Song K, He Q.
    Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2004 Jun; 29(3):257-60. PubMed ID: 16136955.
    Abstract:
    OBJECTIVE: To determine the effects of an antioxidant (An7845) on the proliferation inhibition and apoptosis induction of a human leukemia cell line (K562). METHODS: We evaluated the effects of An7845 on K562 cell proliferation by cellular enumeration in liquid culture assay, MTT assay and colony formation assay. We also verified the effects of An7845 on K562 cell apoptosis by cellular morphology and the DNA fragments appeared in agarose gel electrophoresis. RESULTS: The proliferation of K562 leukemia cells was inhibited by An7845 (5 x 10(-8) - 5 x 10(5) mol/L) in a dose-dependent manner. K562 cells were induced toward apoptosis by An7845 (5 x 10(-7) mol/L). CONCLUSION: An7845 can effectively inhibit the proliferation and induce the apoptosis of K562 leukemia cells.
    [Abstract] [Full Text] [Related] [New Search]