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  • Title: [Mechanisms of dibutyl phthalate to purge leukemic cells].
    Author: Wan WQ, Liu XY, Deng B.
    Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2004 Feb; 29(1):79-80. PubMed ID: 16137013.
    Abstract:
    OBJECTIVE: To determine the mechanism of dibutyl phthalate (DBP) to purge leukemic cells by inducing apoptosis. METHODS: The effects of DBP on the intracellular free Ca2+ concentration ([Ca2+]i) of leukemic cells were measured by Fura-2AM method. The effects of DBP on the protein expression of c-myc and bcl-2 genes of leukemic cells were measured by immunohistochemical assay. RESULTS: DBP elicited an intracellular Ca2+ redistribution and a potent extracellular calcium influx in leukemic cells. It also down-regulated the protein expression of c-myc and bcl-2 genes. CONCLUSION: DBP can purge leukemic cells in vitro by increasing [Ca2+]i in cells to initiate apoptosis and down-regulate bcl-2 and c-myc proto-gene expression to promote the cell apoptosis.
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