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  • Title: [Effect of soybean isoflavone on the cognitive function in ovariectomized mice].
    Author: Zhu JL, Yang GL, Huang YM.
    Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2004 Feb; 29(1):81-3. PubMed ID: 16137014.
    Abstract:
    OBJECTIVE: To explore the effect of soybean isoflavone on the cognitive function in ovariectomized mice and to study the cognitive function mechanism of soybean isoflavone. METHODS: Forty-five Kunming female mice were randomly assigned into 5 groups: A (sham operated); B (ovariectomized, OVX); C (OVX + low dose soybean isoflavone); D (OVX + moderate dose soybean isoflavone); and E (OVX + high dose soybean isoflavone). The experiment lasted 60 days. RESULTS: Ovariectomy significantly elongated the destination time of water maze, shortened the latent time of step-down test, decreased SOD of serum and Na+ K+ -ATPase and Ca2+ Mg2+ -ATPase of brain, and increased malonaldehyde of serum and monoamine oxidase of brain, which-could be inhibited by soybean isoflavone consumption. CONCLUSION: The continuous oral administration of soybean isoflavone can improve the cognitive function of ovariectomized mice.
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