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  • Title: A rare case of bronchial stenosis in Wegener's granulomatosis. Dramatic response to intravenous cyclophosphamide and oral cotrimoxazole.
    Author: Hirsch MM, Houssiau FA, Collard P, Devogelaer JP, Nagant de Deuxchaisnes C.
    Journal: J Rheumatol; 1992 May; 19(5):821-4. PubMed ID: 1613718.
    Abstract:
    We describe a patient with Wegener's granulomatosis (WG) who developed as the only pulmonary manifestation a severe proximal bronchial stenosis despite conventional treatment with steroids and oral cyclophosphamide. The patient subsequently responded to a combined therapy with intravenous (IV) cyclophosphamide and oral cotrimoxazole. We stress the rarity of bronchial involvement in WG and discuss the role of IV cyclophosphamide and cotrimoxazole in the management of this disease.
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