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  • Title: Toll-like receptor-2 deficiency is associated with enhanced brain TNF gene expression during pneumococcal meningitis.
    Author: Letiembre M, Echchannaoui H, Ferracin F, Rivest S, Landmann R.
    Journal: J Neuroimmunol; 2005 Nov; 168(1-2):21-33. PubMed ID: 16137770.
    Abstract:
    TNF is a marker of disease activity in bacterial meningitis. To investigate TNF modulation by Toll-like receptor-2 (TLR2), we studied temporal and anatomical expression patterns of TLR2 and TNF in a pneumococcal meningitis model in wild type (wt) and TLR2(-/-) mice. We show by in situ hybridization that transcripts of TLR2 and of the comolecules CD14, MD-2, TLR1/6 strongly increased and colocalized with TNF in CD45-positive infiltrating cells in the ventricles, corpus callosum and the meninges. TNF gene and protein expression was stronger in TLR2(-/-) than wt brains and associated with increased IkappaB expression suggesting that TLR2 is controlling inflammation via TNF regulation.
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