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  • Title: Partial tandem duplication of MLL gene in acute myeloid leukemia with translocation (11;17)(q23;q12-21).
    Author: Yamamoto S, Nishi M, Taniguchi K, Imayoshi M, Ogata Y, Iwanaga M, Sakai N, Hamasaki Y, Ishii E.
    Journal: Am J Hematol; 2005 Sep; 80(1):46-9. PubMed ID: 16138343.
    Abstract:
    Translocation 11q23 and MLL gene rearrangements are commonly observed in acute myeloid leukemia (AML) in association with the myelomonocytic or monocytic feature. We describe a case involving a 15-year-old patient with AML characterized by leukemic cells exhibiting translocation (11;17)(q23;q12-21) and MLL gene rearrangement. No fusion partner gene of the MLL gene was identified, including RARalpha(17q12) or AF17 (17q21); however, a partial tandem duplication of the MLL exon 11/exon 10 was detected in leukemic cells via a 3'RACE method for detection of unknown partner genes. The patient has been in remission for more than 2 years without hematopoietic stem cell transplantation.
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