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  • Title: [Clinical study of panipenem/betamipron for burn infections in the domain of plastic and reconstructive surgery].
    Author: Yoshida T, Narumi E, Murazumi M, Kamo R, Ohura T, Sakamura R, Iida K, Honda K, Yamamoto Y, Kimura C.
    Journal: Jpn J Antibiot; 1992 Feb; 45(2):181-7. PubMed ID: 1613971.
    Abstract:
    The effectiveness and the safety of panipenem/betamipron, new antibiotics of the carbapenems for burn infections, were studied and the following results were obtained: 1. The preparation, 0.5 g/0.5 g, was administered by intravenous drip infusion twice a day to 11 cases of patients with burn infections. In 10 cases for which clinical effects were evaluable, results were rated as "excellent" in 2 cases, "good" in 2 cases and "fair" in 6 cases, with an efficacy rate of 40%. 2. Penetration to the affected tissue was studied in 2 cases. The tissue level of panipenem was 0.20 micrograms/g immediately after the end of drip infusion and 6.86 micrograms/g 60 minutes thereafter. 3. As for the safety, a slight increase in GOT, GPT and Al-P was noted in 1 case; a slight increase in GPT, NAG and beta 2MG was found in 1 case; and a slight increase in GOT, GPT, Al-P and LAP was noted in 1 case, as abnormal variations in laboratory test results.
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