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  • Title: New 1,2,3,4-tetrahydro-1-aza-anthraquinones and 2-aminoalkyl compounds from norlapachol with molluscicidal activity.
    Author: Barbosa TP, Camara CA, Silva TM, Martins RM, Pinto AC, Vargas MD.
    Journal: Bioorg Med Chem; 2005 Dec 01; 13(23):6464-9. PubMed ID: 16140019.
    Abstract:
    New nitrogen derivatives from norlapachol, including four new diastereomeric 1,2,3,4-tetrahydro-1-aza-anthraquinones obtained from the Prins cyclization on suitable aminoacetaldehyde dimethylacetal derivatives with formic acid, were found to exhibit molluscicidal activity against Biomphalaria glabrata. These derivatives showed low to medium LC(50) values, similar to those reported previously for the homologous series of nitrogen derivatives of lapachol. The toxicity profile against Artemia salina was also determined for all compounds.
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