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  • Title: Plasmodium falciparum: interaction of shikimate analogues with antimalarial drugs.
    Author: McRobert L, Jiang S, Stead A, McConkey GA.
    Journal: Exp Parasitol; 2005 Nov; 111(3):178-81. PubMed ID: 16140296.
    Abstract:
    The shikimate pathway for aromatic biosynthesis presents a target for antimalarial drug development as this pathway is absent from animals. This study extends previous work on inhibitors of the shikimate pathway, by examining their interaction with the antimalarial drugs pyrimethamine and atovaquone. Combinations of atovaquone with several shikimate analogues exhibited synergistic effects. These findings highlight potential use of shikimate pathway inhibitors in combination therapy.
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