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  • Title: A fluorogenic and chromogenic probe that detects the esterase activity of trace copper(II).
    Author: Kierat RM, Krämer R.
    Journal: Bioorg Med Chem Lett; 2005 Nov 01; 15(21):4824-7. PubMed ID: 16140531.
    Abstract:
    Bis(picolinoyl)fluorescein, a new fluorogenic and chromogenic probe for monitoring the esterase activity of metal ions, has been synthesized. The probe is highly selective for Cu2+ and is applicable both to quantification of the free ion and detection of esterolytic activity of Cu bound to organic ligands or biomolecules, with a detection limit of 100 nM by fluorimetry.
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