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  • Title: Reduced prepulse inhibition of startle in STAT6-deficient mice.
    Author: Yukawa K, Tanaka T, Owada-Makabe K, Tsubota Y, Bai T, Maeda M, Takeda K, Akira S, Iso H.
    Journal: Int J Mol Med; 2005 Oct; 16(4):673-5. PubMed ID: 16142403.
    Abstract:
    To determine the role of STAT6 transcription factors in brain function, we performed a battery of mouse behavioral analyses of STAT6-deficient mice. We recently showed that STAT6-deficient mice displayed increased locomotor activities and had reduced levels of dopamine transporter (DAT) expression in the striatum. To further examine the behavioral effects of STAT6 deficiency, we subjected STAT6-deficient mice to behavior task testing prepulse inhibition (PPI) of the auditory startle response. In acoustic prepulse conditions, STAT6-deficient mice displayed significantly lower levels of PPI in acoustic startle than did wild-type mice, indicating their sensorimotor gating deficits. Thus, STAT6 transcription factors may be crucially implicated in sensorimotor gating by modulating the expression of several genes, including DAT in brain neurons.
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