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  • Title: Synthesis and evaluation of 3-anilino-quinoxalinones as glycogen phosphorylase inhibitors.
    Author: Dudash J, Zhang Y, Moore JB, Look R, Liang Y, Beavers MP, Conway BR, Rybczynski PJ, Demarest KT.
    Journal: Bioorg Med Chem Lett; 2005 Nov 01; 15(21):4790-3. PubMed ID: 16143521.
    Abstract:
    A series of 3-anilino-quinoxalinones has been identified as a new class of glycogen phosphorylase inhibitors. The lead compound 1 was identified through high throughput screening as well as through pharmacophore-based electronic screening. Modifications were made to the scaffold of 1 to produce novel analogues, some of which are 25 times more potent than the lead compound.
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