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  • Title: Synthesis of potent and selective serotonin 5-HT1B receptor ligands.
    Author: Huang Y, Bae SA, Roth BL, Laruelle M.
    Journal: Bioorg Med Chem Lett; 2005 Nov 01; 15(21):4786-9. PubMed ID: 16143528.
    Abstract:
    A series of serotonin 5-HT1B ligands were synthesized and evaluated for their potency and selectivity against other 5-HT receptor subtypes. Many of these new compounds displayed high affinity and selectivity for the 5-HT1B receptor and compound 6c was found to have the in vitro binding profile necessary for development as a PET radioligand.
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