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  • Title: Total synthesis and further scrutiny of the in vitro antifungal activity of 6-nonadecynoic acid.
    Author: Carballeira NM, Sanabria D, Parang K.
    Journal: Arch Pharm (Weinheim); 2005 Sep; 338(9):441-3. PubMed ID: 16143955.
    Abstract:
    The antifungal, naturally occurring acetylenic fatty acid 6-nonadecynoic acid was synthesized in three steps (18 % overall yield), for the first time starting with commercially available 1-tetradecyne. The synthesis developed herein will facilitate the further study of the antifungal properties of this naturally occurring acetylenic fatty acid. The 6-nonadecynoic acid exhibited the best antifungal activity (< 4.3 microM) against Cryptococcus neoformans ATCC 66031 in Sabouraud Dextrose Broth (SDB) media. In our hands, it was not active against Candida albicans ATCC 14053 and Candida albicans ATCC 60193.
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