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  • Title: [Maternal serum lipid at 36-42 weeks' gestation and their relationship to newborn weight in pregnant women with gestational diabetes mellitus and type 1 and type 2 diabetes mellitus].
    Author: He B, Li SQ, Wang W, Han P.
    Journal: Zhonghua Fu Chan Ke Za Zhi; 2004 Oct; 39(10):675-7. PubMed ID: 16144564.
    Abstract:
    OBJECTIVE: To investigate the levels of serum lipid at 36 - 42 weeks' gestation and their relationship to newborn weight in pregnant women with gestational diabetes mellitus (GDM) and type 1 and type 2 diabetes mellitus (DM). METHODS: This study included 30 normal pregnant women, 40 patients with GDM, 30 patients with type 1 DM and 30 with type 2 DM. Subjects with complications including hypertension or thyreogenic diseases were excluded. Fasting serum triglyceride, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol were measured by enzymatic method. RESULTS: (1) Serum triglyceride levels in pregnant women with GDM, type 1 DM, type 2 DM and normal controls were (4.0 +/- 1.4) mmol/L, (2.9 +/- 0.8) mmol/L, (4.1 +/- 2.5) mmol/L and (2.7 +/- 0.9) mmol/L respectively; the total cholesterol levels were (6.5 +/- 3.0) mmol/L, (6.2 +/- 2.8) mmol/L, (6.4 +/- 3.2) mmol/L and (6.0 +/- 3.0) mmol/L respectively; low density lipoprotein cholesterol levels were (3.2 +/- 1.3) mmol/L, (3.2 +/- 1.3) mmol/L, (3.3 +/- 1.1) mmol/L and (3.2 +/- 1.0) mmol/L respectively; high density lipoprotein cholesterol levels were (1.6 +/- 0.5) mmol/L, (1.4 +/- 0.5) mmol/L, (1.5 +/- 0.4) mmol/L and (1.6 +/- 0.4) mmol/L respectively; the newborn weights were (4108 +/- 544) g, (3323 +/- 457) g, (4111 +/- 263) g, and (3463 +/- 516) g respectively. Triglyceride levels in pregnant women with GDM and type 2 DM were significantly higher than in normal controls and type 1 DM patients (P < 0.01). (2) Triglyceride levels correlated with birth weights independently (r = 0.39, P < 0.01). CONCLUSIONS: Triglyceride levels at 36-42 weeks' gestation were elevated in pregnant women with GDM and type 2 DM, suggesting that they might have more obvious insulin resistance. In pregnant women with DM, a positive and significant correlation was found between triglyceride levels and newborn weights.
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