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  • Title: Dapsone for chronic idiopathic thrombocytopenic purpura in children and adults--a report on 90 patients.
    Author: Damodar S, Viswabandya A, George B, Mathews V, Chandy M, Srivastava A.
    Journal: Eur J Haematol; 2005 Oct; 75(4):328-31. PubMed ID: 16146539.
    Abstract:
    Data on 90 patients (55 adults and 35 children) with chronic idiopathic thrombocytopenic purpura (ITP) and a platelet count of <50 x 10(9)/L treated with dapsone at a dose of 1-2 mg/kg/d are presented. A response was observed in 57 (63.3%) patients. The average time for response was 3.5 months (range 1-9) and the average duration of treatment with dapsone was 10.4 months (range 4-14). Overall response rates of 65.7% and 61.8% were observed in children and adults respectively. Side effects requiring discontinuation of therapy were observed in three (2%) patients. These results demonstrate that dapsone is an effective, inexpensive and well-tolerated treatment for chronic ITP, in both children and adults and could be considered for patients who fail steroid therapy.
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