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  • Title: [Fetal warfarin syndrome in twin pregnancy].
    Author: Królak-Olejnik B, Pyrkosz A, Lagan J, Zembala-Nozyńska E, Kaźmierczak W.
    Journal: Ginekol Pol; 2005 Jun; 76(6):476-80. PubMed ID: 16149266.
    Abstract:
    We describe a pair of twins, whose mother was being treated by oral anticoagulant drugs, as a result of having received mitral heart valve implantation in the past. The male twins monochorionic, monoamniotic--but one infant showed the features of fetal warfarin syndrome. In the study we discussed the pharmacogentetics and individual variation in the human metabolism during treatment with warfarin-perinatal growth and prevalence of congenital malformations. We analysed the threats to the fetus and mother, connected with administration of anticoagulant drugs.
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