These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Comparison of the TDx-FLM II and lecithin to sphingomyelin ratio assays in predicting fetal lung maturity.
    Author: Winn-McMillan T, Karon BS.
    Journal: Am J Obstet Gynecol; 2005 Sep; 193(3 Pt 1):778-82. PubMed ID: 16150274.
    Abstract:
    OBJECTIVE: We evaluated the usefulness of the TDx-FLM II and lecithin to sphingomyelin (L/S) ratio assays in predicting fetal lung maturity. STUDY DESIGN: We retrospectively reviewed 218 consecutive paired TDx-FLM II and L/S ratio results. Women who delivered viable infants within 72 hours of amniotic fluid collection (n=109) were included in the analysis of sensitivity and specificity. Concordance between tests was determined for all women tested during the study period, and in the subset of women who delivered viable infants within 72 hours of amniotic fluid collection. RESULTS: There were 9 respiratory distress syndrome (RDS)-affected infants born during the study period. Both the TDx-FLM II and L/S ratios had 100% sensitivity in detecting RDS at their best apparent cut-offs. There was a trend towards increased specificity of the L/S ratio compared with the TDx-FLM II (80% for L/S vs 73% for FLM II). The overall concordance between the TDx-FLM II and L/S ratio was approximately 75%. CONCLUSION: The TDx-FLM II and L/S ratios are both sensitive tests for RDS; however, there is not good concordance between the two. The results provide new insight into the optimal use, in sequential or reflex cascade testing, of the TDx-FLM II and L/S ratio.
    [Abstract] [Full Text] [Related] [New Search]