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  • Title: Haloperidol reduces ethanol-induced motor activity stimulation but not conditioned place preference.
    Author: Risinger FO, Dickinson SD, Cunningham CL.
    Journal: Psychopharmacology (Berl); 1992; 107(2-3):453-6. PubMed ID: 1615143.
    Abstract:
    This experiment examined the impact of a dopamine receptor blocker on ethanol's rewarding effect in a place conditioning paradigm. DBA/2J mice received four pairings of a tactile stimulus with ethanol (2 g/kg, IP), haloperidol (0.1 mg/kg, IP)+ethanol, or haloperidol alone. A different stimulus was paired with saline. Ethanol produced increases in locomotor activity that were reduced by haloperidol. However, conditioned preference for the ethanol-paired stimulus was not affected by haloperidol. Haloperidol alone decreased locomotor activity during conditioning and produced a place aversion. These results indicate a dissociation of ethanol's activating and rewarding effects. Moreover, they suggest that ethanol's ability to induce conditioned place preference is mediated by nondopaminergic mechanisms.
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