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  • Title: Detection of nitrous oxide in the neuronal nitric oxide synthase reaction by gas chromatography-mass spectrometry.
    Author: Ishimura Y, Gao YT, Panda SP, Roman LJ, Masters BS, Weintraub ST.
    Journal: Biochem Biophys Res Commun; 2005 Dec 09; 338(1):543-9. PubMed ID: 16154533.
    Abstract:
    Using headspace gas chromatography-mass spectrometry, we detected significant amounts of nitrous oxide in the reaction products of the monooxygenase reaction catalyzed by neuronal nitric oxide synthase. Nitrous oxide is a dimerization product of nitroxyl anion; its presence in the reaction products indicates that the nitroxyl anion is a product of the neuronal nitric oxide synthase-catalyzed reaction.
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