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  • Title: Allosteric modulation of the nicotinic acetylcholine receptor by physostigmine.
    Author: Svobodová L, Krusek J, Hendrych T, Vyskocil F.
    Journal: Ann N Y Acad Sci; 2005 Jun; 1048():355-8. PubMed ID: 16154951.
    Abstract:
    The action of physostigmine on mouse muscle nicotinic acetylcholine receptor expressed in the COS-7 cell line was studied by the patch-clamp technique. Physostigmine accelerated, by allosteric modulation, the rate of desensitization of whole cell currents induced by acetylcholine and decreased the maximal amplitude in concentration-dependent manner.
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