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  • Title: Structural basis for anticodon recognition by methionyl-tRNA synthetase.
    Author: Nakanishi K, Ogiso Y, Nakama T, Fukai S, Nureki O.
    Journal: Nat Struct Mol Biol; 2005 Oct; 12(10):931-2. PubMed ID: 16155581.
    Abstract:
    In the 2.7-A resolution crystal structure of methionyl-tRNA synthetase (MetRS) in complex with tRNA(Met) and a methionyl-adenylate analog, the tRNA anticodon loop is distorted to form a triple-base stack comprising C34, A35 and A38. A tryptophan residue stacks on C34 to extend the triple-base stack. In addition, C34 forms Watson-Crick-type hydrogen bonds with Arg357. This structure resolves the longstanding question of how MetRS specifically recognizes tRNA(Met).
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