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  • Title: [Expression and significance of VEGF, VEGF-C, and VEGF-D in papillary thyroid carcinoma].
    Author: Jiang HG, Gao M, Tang WP, Li FH, Cai QZ.
    Journal: Ai Zheng; 2005 Sep; 24(9):1136-9. PubMed ID: 16159441.
    Abstract:
    BACKGROUND & OBJECTIVE: Vascular endothelial growth factor-C and -D (VEGF-C, VEGF-D) are related to lymphangiogenesis. Papillary thyroid carcinoma is characterized by regional lymph node metastasis. This study was designed to determine the expression and significance of VEGF, VEGF-C, and VEGF-D in papillary thyroid carcinoma. METHODS: The expression of VEGF, VEGF-C, and VEGF-D in 115 specimens of papillary thyroid carcinoma and 20 specimens of nodular goiter were detected by SP immunohistochemistry. RESULTS: Positive rates of VEGF, VEGF-C, and VEGF-D were significantly higher in papillary thyroid carcinoma than in nodular goiter (79.1% vs. 30.0%, 87.0% vs. 15.0%, and 72.2% vs. 20.0%, P<0.01). The expression of VEGF was closely related to the size of papillary thyroid carcinoma. Positive rates of VEGF were 84.7% in lymph node positive group, and 73.2% in lymph node negative group. Positive rates of VEGF-C and VEGF-D were significantly higher in lymph node positive group than in lymph node negative group (93.2% vs. 80.4%, P<0.05; 83.1% vs. 60.7%, P<0.01). CONCLUSION: VEGF is closely related to tumor growth of papillary thyroid carcinoma; while VEGF-C and VEGF-D are closely related to lymph node metastasis of papillary thyroid carcinoma, and may be predictors of lymph node metastasis.
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