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  • Title: [Methacholine challenge in young children: measurement of resistance by interruption].
    Author: Beydon N, Matran R, Wuyam B, Amsallem F, Boule M, Alberti C, Denjean A, Gaultier C, Groupe Pédiatrique Français du PHRC.
    Journal: Rev Mal Respir; 2005 Dec; 22(6 Pt 1):959-66. PubMed ID: 16160677.
    Abstract:
    The aims of this study were 1. To evaluate the measurement of resistance by interruption (Rint) of bronchoconstriction induced by inhalation of methacholine and 2. To determine a threshold of increase of resistance in young children to differentiate responders from non-responders. Forty-six children (mean age 5 [4.3-6.1] years) referred for methacholine challenge were tested by measurement of Rint and transcutaneous oxygen tension. A fall of 20% or more in oxygen tension from the baseline was used to define the responders. The children studied had a baseline Rint significantly higher than normal (0.84 [0.68-1.01] vs. 0.76 [0.60-0.90] kPa L(-1)s; p < 0.03). Forty-one children were responders and had an increase in Rint significantly different from the non-responders (p < 0/04). An increase in Rint of 35% distinguished responders from non-responders in young children with chronic cough. Interrupter resistance increases significantly during bronchial provocation in responding young children and may be used to measure the degree of bronchoconstriction.
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