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  • Title: [Agranular CD4+/CD56+ haematodermic neoplasm (Precursor haematologic neoplasm)].
    Author: Török L, Krenács L, Kocsis L, Gurzó M, Bagdi E, Varga G, Gogolák P.
    Journal: Orv Hetil; 2005 Jul 31; 146(31):1647-50. PubMed ID: 16161251.
    Abstract:
    The agranular CD4+/CD56+ haematodermic neoplasm (so-called blastic NK-cell lymphoma) represents a distinct clinicopathologic entity and it is characterised by its clinical presentation (skin tropism, bone marrow involvement with or without leukemic phase, very poor prognosis) and the common expression of the T helper CD4 as well as the NK cell marker CD56. The authors present an 86 year old male patient with hemorrhagic macules, plaques and hemorrhagic flat nodules mainly on the trunk without any complaints. The skin biopsy revealed an agranular CD4+/CD56+ hematodermic tumor. During the medical check-up and the 18 months long follow-up they did not find any internal involvement including the bone marrow. In their case they revealed the cutaneous form of the hematodermic tumor which is considered to be a new and interesting manifestation of aleukemic leukemia cutis.
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