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  • Title: Histaminergic response to Coriolis stimulation: implication for transdermal scopolamine therapy of motion sickness.
    Author: Wang ET, Zhou DR, He LH.
    Journal: Aviat Space Environ Med; 1992 Jul; 63(7):579-82. PubMed ID: 1616432.
    Abstract:
    The blood levels of histamine and 5-hydroxytryptamine (5-HT) in 10 subjects, with or without administration of the transdermal therapeutic system of scopolamine (TTS-S), were measured following motion sickness (MS) induced by Coriolis stimulation. Histamine and 5-HT were assayed using the fluorometric method. The results demonstrated that the blood levels of histamine increased significantly following MS and were even higher in the subjects using TTS-S, but we found neither significant changes in the blood levels of 5-HT following MS nor any effect of TTS-S on it. The results suggest that histamine contributes to the development of MS, and scopolamine may exert its anti-MS action by affecting the histaminergic system as well as the acetylcholinergic system; there may not be a definite relation between 5-HT and the development of MS.
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