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  • Title: Alopecia areata treatment with a phototoxic dose of UVA and topical 8-methoxypsoralen.
    Author: Mohamed Z, Bhouri A, Jallouli A, Fazaa B, Kamoun MR, Mokhtar I.
    Journal: J Eur Acad Dermatol Venereol; 2005 Sep; 19(5):552-5. PubMed ID: 16164707.
    Abstract:
    Twenty-five patients with alopecia totalis (AT) or alopecia universalis and 124 patients with alopecia areata (AA) were treated with photochemotherapy, combining topical 8-methoxypsoralen (8-MOP) with UV irradiation of the scalp at a phototoxic dose. The mean energy required was 15 J/cm2 for AA and 42 J/cm2 for AT. Ninety-four patients had multiple bald patches and 12 with AT had complete or > 50% hair regrowth. Positive treatment results did not seem to depend on the age of onset or the duration of the disease. Few side-effects of topical psoralens plus UVA (PUVA) treatment were noted, except a for few days of slight erythema caused by the high dose of UV.
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