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  • Title: [Clinical analysis of Peutz-Jeghers syndrome:a report of 6 cases].
    Author: Dong K, Li B, Li BH, Guan QL, Huo YZ.
    Journal: Zhonghua Wei Chang Wai Ke Za Zhi; 2005 Jul; 8(4):336-8. PubMed ID: 16167257.
    Abstract:
    OBJECTIVE: To investigate the diagnostic methods and reasonable treatment of Peutz-Jeghers syndrome (PJS). METHODS: Clinical data of six patients with PJS were reviewed. RESULTS: Repeated abdominal pain, intussusception and intestinal polyp with bleeding were main manifestations. Four patients father,three patients grandfather and one patients mother were diagnosed with PJS. Three patients had family history of cancer. Case 4 and case 5 underwent laparotomy for many times because of intussusceptions caused by polyps or recurrent abdominal pain. Case 1 and case 4 had polyps synchronous with adenoma, and case 2 had polyp with gastric cancer. Main treatment included polyp resection and partial small intestinal and colon resection. CONCLUSIONS: Patients with PJS have family history of cancer and a high incidence of polyp recurrence of small intestine. Surgical intervention is the first choice regimen. Surveillance should be emphasized on gastrointestinal tract and other potential malignant organs in PJS patients.
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