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  • Title: Synthesis and evaluation of antiplatelet activity of trihydroxychalcone derivatives.
    Author: Zhao LM, Jin HS, Sun LP, Piao HR, Quan ZS.
    Journal: Bioorg Med Chem Lett; 2005 Nov 15; 15(22):5027-9. PubMed ID: 16169724.
    Abstract:
    In an effort to develop potent antiplatelet agents, a series of trihydroxychalcones was synthesized and screened in vitro for their inhibitory effects on washed rabbit platelet aggregation induced by arachidonic acid (100 microM) and collagen (10 microg/ml). Of five compounds with potent inhibitory effects on arachidonic acid- and collagen-induced platelet aggregation, compound 4e was found to be the most potent. The structure-activity relationships suggested that antiplatelet activity was governed to a greater extent by the substituent on B ring of the chalcone template, and most of the active compounds had methoxy or dimethoxy groups on B ring.
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